Unexplained Infertility in Young Couples: What to Know Early On

Unexplained Infertility in Young Couples explained by Dr Manju Khurana

Fertility is often taken for granted by young, healthy couples—until conception doesn’t happen. While age-related fertility decline is commonly discussed, a growing number of couples in their 20s and 30s are facing a surprising challenge: unexplained infertility. Despite regular ovulation, healthy sperm, and open fallopian tubes, some couples find themselves unable to conceive without any identifiable cause.

At Gobind Fertility & IVF Centre, we understand how emotionally and physically exhausting this journey can be. In this article, we’ll dive into what unexplained infertility is, the early signs, possible causes, and what steps young couples can take to overcome it.

Unexplained Infertility is a diagnosis given when standard fertility tests (such as ovulation tracking, semen analysis, and evaluation of the uterus and fallopian tubes) return normal results, but pregnancy still does not occur after 12 months of unprotected intercourse.

In medical terms, 10-20% of all infertility cases fall into the “unexplained” category. This can be incredibly frustrating because there is no obvious issue to treat — yet, conception doesn’t happen.

While unexplained infertility lacks a clear diagnosis, some subtle symptoms or patterns may raise concern:

  • No pregnancy after one year of regular, unprotected sex
  • Regular periods but still not conceiving
  • Mild hormonal imbalances not flagged as abnormal
  • Early miscarriages with no known cause
  • Subtle changes in cycle length or quality of cervical mucus

If you are experiencing any of these issues, it’s wise to consult a fertility specialist early on, especially if you’re under 35 and have been trying for a year (or 6 months if over 35).

Though conventional testing might not reveal the issue, several subtle or microscopic factors may be contributing:

  1. Egg Quality Issues
    Even in younger women, poor egg quality can hinder fertilisation or embryo development.
  2. Sperm DNA Fragmentation
    A normal semen analysis does not assess sperm DNA integrity. Damaged sperm DNA can impact fertilisation and embryo implantation.
  3. Immunological Factors
    Some women may produce antibodies that attack sperm or embryos, affecting implantation.
  4. Endometriosis (Mild/Hidden)
    Mild forms of endometriosis may not show up in standard imaging but can still affect fertility.
  5. Tubal Dysfunction
    Even if fallopian tubes are open, their function may be impaired, preventing the egg and sperm from meeting.
  6. Implantation Failure
    Issues in the uterine lining or embryo communication with the uterus can prevent successful implantation.

Young couples often feel blindsided by a diagnosis of unexplained infertility. The lack of answers can lead to:

  • Anxiety and depression
  • Stress in relationships
  • Feelings of guilt or inadequacy
  • Emotional burnout from repeated failed attempts

At Gobind Fertility & IVF Centre, we emphasise compassionate counselling along with medical treatment to support mental and emotional well-being throughout the fertility journey.

If you and your partner have been trying to conceive for a year without success (or six months if the woman is over 35), it’s time to consult a fertility expert. Don’t wait to get help — early intervention often leads to better outcomes.

Some tests your fertility specialist may recommend:

  • Detailed ovulation tracking
  • Advanced semen analysis
  • Hysterosalpingography (HSG)
  • Anti-Müllerian Hormone (AMH) testing for ovarian reserve
  • Laparoscopy (to check for hidden endometriosis)
  • Uterine evaluation through hysteroscopy

At Gobind Fertility & IVF Centre, we tailor every fertility treatment plan to the couple’s age, medical history, and individual preferences. Some common fertility treatments for unexplained infertility include:

  • Weight management
  • Balanced diet and regular exercise
  • Reducing alcohol, caffeine, and smoking
  • Stress reduction techniques like yoga, meditation, and therapy

Mild fertility drugs such as Clomiphene Citrate or Letrozole are prescribed to enhance ovulation, combined with tracking the fertile window.

IUI increases the chances of conception by placing concentrated sperm directly into the uterus around the time of ovulation.

IVF offers a higher success rate and allows embryologists to monitor fertilisation and embryo quality. IVF also helps bypass subtle issues like tubal dysfunction or sperm abnormalities.

In cases of unexplained infertility related to sperm DNA or failed fertilisation, ICSI—where a single sperm is injected into the egg—can significantly improve outcomes.

PGT can help identify genetically normal embryos, reducing the risk of miscarriage and implantation failure.

At Gobind Fertility & IVF Centre, we specialise in evidence-based fertility treatments for couples of all ages. Our dedicated team of fertility experts, embryologists, and counsellors work together to provide:

  • Advanced diagnostics for unexplained infertility
  • High success rates in IUI and IVF treatments
  • Customised treatment protocols for each couple
  • Transparent communication and emotional support

We believe that early diagnosis and a personalised approach can turn even the most confusing infertility cases into a success story.

Unexplained infertility in young couples can be disheartening, but it is far from hopeless. With the right combination of expert care, emotional support, and cutting-edge fertility treatment, many couples go on to achieve a successful pregnancy.

If you’ve been trying to conceive without results, don’t wait. Schedule a consultation at Gobind Fertility & IVF Centre today — and take your first step towards parenthood.

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